Physical Property Scaling Relationships for Polyelectrolyte Complex Micelles

Complex Formation between Polyelectrolyte and Oppositely Charged Mixed Micelles

Electrophoretic light scattering, dynamic light scattering, turbidity, and static light scattering were used to study complex formation between poly(dimethyldiallylammonium chloride) (PDMDAAC) and oppositely charged mixed micelles of Triton X-100 (TX100) and sodium dodecyl sulfate (SDS) in 0.4 M NaC1. Interpolymer complexes form with an increasing bulk weight ratio of PDMDAAC to TX100-SDS, W, a...

Inhibition of atherosclerosis-promoting microRNAs via targeted polyelectrolyte complex micelles.

Polyelectrolyte complex micelles have great potential as gene delivery vehicles because of their ability to encapsulate charged nucleic acids forming a core by neutralizing their charge, while simultaneously protecting the nucleic acids from non-specific interactions and enzymatic degradation. Furthermore, to enhance specificity and transfection efficiency, polyelectrolyte complex micelles can ...

Complex Formation between Polyelectrolyte and Oppositely Charged Mixed Micelles: Soluble Complexes vs Coacervation

The system comprised of poly(dimethyldially1ammonium chloride) (PDMDAAC) and oppositely charged mixed micelles of Triton X-100 (TXlOO) and sodium dodecylsulfate (SDS) displays several states, including coacervate and various soluble complexes. The phase boundary for the equilibrium between soluble complexes and coacervate (“associative phase separation” according to Piculell and Lindman) for 0....

In vivo tumor targeting of ODN-PEG-folic acid/PEI polyelectrolyte complex micelles.

A tumor-targeting antisense oligodeoxynucleotide (ODN) delivery system based on polyelectrolyte complex (PEC) micelles is demonstrated. ODN-PEG-folic acid (ODN-PEG-FA) was synthesized using a heterofunctional PEG linker. The PEC micelles for the targeted ODN delivery to tumor cells were produced by ionic interactions between the ODN-PEG-FA and polyethylenimine (PEI). The in vivo targeting prope...

Structure-Property Relationships of Surfactants at Interfaces and Polyelectrolyte-Surfactant Aggregates